Two sample MR report
TAGLN_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.1351696 | 1.0363801 | 0.9025266 |
| Weighted median | 6 | -0.0840144 | 0.0472456 | 0.0753632 |
| Inverse variance weighted | 6 | -0.0812157 | 0.0388291 | 0.0364723 |
| Simple mode | 6 | -0.0845773 | 0.0601746 | 0.2188523 |
| Weighted mode | 6 | -0.0845773 | 0.0607992 | 0.2229250 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0135739 | 4 | 0.9999771 |
| Inverse variance weighted | 0.0162879 | 5 | 0.9999982 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0619331 | 1.188816 | 0.9609497 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.74e-05 | 0 | TRUE | 0.5608002 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
